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Generic Name: salsalate (SAL sa late)
Brand Names: Disalcid, Salsitab

What is Disalcid (salsalate)?

Salsalate is in a class of drugs called salicylates. It works by reducing substances in the body that cause pain and inflammation.

Salsalate is used to reduce pain and inflammation caused by conditions such as rheumatoid arthritis, osteoarthritis, and related rheumatic conditions.

Salsalate may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Disalcid (salsalate)?

Watch for bloody, black, or tarry stools or blood in your vomit. These symptoms could indicate damage to the stomach.

What should I discuss with my healthcare provider before taking Disalcid (salsalate)?

Before taking this medication, tell your doctor if you

• have an allergy to aspirin or any other NSAIDs,

• have an ulcer or bleeding in your stomach,

• drink more than three alcoholic beverages a day,

• have liver or kidney disease,

• have a coagulation (bleeding) disorder,

• have congestive heart failure,

• have fluid retention,

• have heart disease, or

• have high blood pressure.

You may not be able to take salsalate, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take Disalcid (salsalate)?

Take salsalate exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Do not take salsalate more often than every 4 hours, and do not take more than is recommended. If your condition does not improve within 3 to 4 days, seek medical attention.

Be aware of the salicylate (aspirin) content of other over-the-counter and prescription products. Care should be taken to avoid taking more than the recommended amount of salicylate per dose or per day.

What happens if I miss a dose?

Take the missed dose as soon as you remember and do not take another dose for at least 4 hours. Do not take a double dose of the medication.

What happens if I overdose?

Symptoms of an salsalate overdose include ringing in the ears, headache, nausea, vomiting, dizziness, confusion, hallucinations, coma, seizures, rapid breathing, and fever.

What should I avoid while taking Disalcid (salsalate)?

Be aware of the salicylate (aspirin) content of other over-the-counter and prescription products. Care should be taken to avoid taking more than the recommended amount of salicylate per dose or per day.

Disalcid (salsalate) side effects

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• black, bloody, or tarry stools;

• nausea, vomiting, or abdominal pain;

• uncontrolled fever;

• blood in urine or vomit;

• decreased hearing or ringing in the ears;

• seizures; or

• dizziness, confusion, or hallucinations.

If you experience any of the following less serious side effects, notify your doctor:

• heartburn or indigestion,

• faint ringing in the ears,

• drowsiness, or

• headache.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Disalcid (salsalate)?

• an anticoagulant such as warfarin (Coumadin), heparin, enoxaparin (Lovenox), dalteparin (Fragmin), danaparoid (Orgaran), ardeparin (Normiflo), or tinzaparin (Innohep);

• a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve), diclofenac (Voltaren, Cataflam), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), sulindac (Clinoril), or tolmetin (Tolectin); or

• another salicylate such as aspirin (Acuprin, Ecotrin, Ascriptin, Bayer, others) or choline salicylate and/or magnesium salicylate (Magan, Doan's, Bayer Select Backache Pain Formula, Mobidin, Arthropan, Trilisate, Tricosal).

You may not be able to take salsalate, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with salsalate. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

• Your pharmacist has additional information about salsalate written for health professionals that you may read.

What does my medication look like?

Salsalate is available with a prescription under the brand names Mono-Gesic, Salflex, Disalcid, and Salsitab. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Mono-Gesic 750 mg--oval, pink, film-coated, bisected tablets

• Salflex 500 mg--oval, white, film-coated, scored tablets

• Salflex 750 mg--white, film-coated, scored tablets

• Disalcid 500 mg--aqua/white capsule

• Disalcid 500 mg--round, aqua, film-coated, bisected tablets

• Disalcid 750 mg--capsule-shaped, aqua, film-coated, bisected tablets

• Salsitab 500 mg--round, blue, film-coated tablets

• Salsitab 750 mg--capsule-shaped, blue, film-coated, scored tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.