ONLINE PHARMACY find all drugs you want

Generic Name: conjugated estrogens (vaginal) (KON joo gay ted ES troe jenz)
Brand Names: Premarin Vaginal

What are conjugated estrogens (vaginal)?

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Conjugated estrogens (vaginal) are a mixture of estrogen hormones used to treat the vaginal symptoms of menopause such as dryness, burning, and irritation.

Conjugated estrogens (vaginal) may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about conjugated estrogens (vaginal)?

Long-term treatment with conjugated estrogens may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using conjugated estrogens (vaginal) long term, especially if you smoke or are overweight. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using conjugated estrogens (vaginal).

What should I discuss with my healthcare provider before using conjugated estrogens (vaginal)?

• a history of heart attack, stroke, or blood clot (especially in your lung or your lower body);

• abnormal vaginal bleeding that a doctor has not checked;

• liver disease; or

• any type of breast, uterine, or hormone-dependent cancer.

Before using conjugated estrogens (vaginal), tell your doctor if you are allergic to any drugs, or if you have:

• high blood pressure, heart disease, or circulation problems;

• a personal or family history of stroke;

• endometriosis;

• liver or kidney disease;

• asthma;

• epilepsy or other seizure disorder;

• migraines;

• diabetes;

• underactive thyroid;

• high cholesterol or triglycerides;

• high or low levels of calcium in your blood;

• porphyria;

• systemic lupus erythematosus (SLE);

• gallbladder disease; or

• if you have had your uterus removed (hysterectomy).

If you have any of these conditions, you may not be able to use conjugated estrogens (vaginal), or you may need a dosage adjustment or special tests during treatment.

Conjugated estrogens (vaginal) increase your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using conjugated estrogens may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using conjugated estrogens (vaginal).

Long-term conjugated estrogens treatment may increase your risk of stroke or blood clots. Talk with your doctor about your individual risks before using conjugated estrogens (vaginal) long term, especially if you smoke or are overweight. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

How should I use conjugated estrogens (vaginal)?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.

Vaginal conjugated estrogens are usually prescribed for only a short time and are most often used in a cycle, such as 3 weeks on followed by 1 week off. Follow the directions on your prescription label.

To apply this medication, use only the vaginal applicator provided. After each use, take the applicator apart and clean it with mild soap and warm water. Do not use hot or boiling water.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis if you are using conjugated estrogens (vaginal) long term.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using conjugated estrogens. You may need to stop using the medicine for a short time.

This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using conjugated estrogens.

What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use your medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

What should I avoid while using conjugated estrogens (vaginal)?

Do not smoke while using this medication. Smoking can increase your risk of blood clots, stroke, or heart attack caused by conjugated estrogens (vaginal).

Conjugated estrogens (vaginal) side effects

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

• sudden numbness or weakness, especially on one side of the body;

• sudden headache, confusion, problems with vision, speech, or balance;

• pain or swelling in your lower leg;

• abnormal vaginal bleeding;

• migraine headache;

• pain, swelling, or tenderness in your stomach;

• confusion, problems with memory or concentration;

• jaundice (yellowing of the skin or eyes);

• swelling in your hands, ankles, or feet; or

• a breast lump.

Continue using conjugated estrogens (vaginal) and talk to your doctor if you have any of these less serious side effects:

• mild nausea, vomiting, bloating, stomach cramps;

• breast pain, tenderness, or swelling;

• freckles or darkening of facial skin;

• increased hair growth, loss of scalp hair;

• changes in weight or appetite;

• problems with contact lenses;

• vaginal itching or discharge;

• changes in your menstrual periods, decreased sex drive; or

• headache, nervousness, dizziness, tired feeling.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect conjugated estrogens (vaginal)?

Before using conjugated estrogens, tell your doctor if you are using any of the following medicines:

• a blood thinner such as warfarin (Coumadin);

• a thyroid medication such as levothyroxine (Synthroid);

• insulin or diabetes medicine taken by mouth;

• rifampin (Rifadin, Rifater, Rifamate, Rimactane);

• ketoconazole (Nizoral) or itraconazole (Sporanox);

• seizure medicines such as phenytoin (Dilantin), carbamazepine (Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or primidone (Mysoline);

• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or

• antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).

If you are using any of these drugs, you may not be able to use conjugated estrogens (vaginal), or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect conjugated estrogens (vaginal). Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about conjugated estrogens (vaginal) written for health professionals that you may read.

What does my medication look like?

Conjugated estrogens (vaginal) is available with a prescription under the brand name Premarin Vaginal Cream. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Premarin Vaginal Cream 0.625 mg/g

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.