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Meridia is used for:

Treating obesity. It should be used with a reduced calorie diet.

Meridia is a diet aid. It appears to work by regulating chemicals in the appetite center in the brain to cause a temporary reduction in hunger or craving for food.

Do NOT use Meridia if:

• you are allergic to any ingredient in Meridia
• you have an eating disorder (eg, anorexia, bulimia), uncontrolled or severe high blood pressure, hardening of the arteries, increased blood pressure in the lungs, or have had a stroke
• you have severe liver or kidney problems or you are on dialysis for severe kidney problems
• you are taking a selective serotonin reuptake inhibitor (SSRI) (eg, fluoxetine), another appetite suppressant, or you have taken a monoamine oxidase inhibitor (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Meridia :

Some medical conditions may interact with Meridia . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney or liver disease, heart disease, increased risk for bleeding, narrow-angle glaucoma, or seizures

Some MEDICINES MAY INTERACT with Meridia . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Dihydroergotamine, imidazoles (eg, itraconazole, ketoconazole), lithium, MAO inhibitors (eg, phenelzine), narcotic analgesics (eg, codeine), SSRIs (eg, fluoxetine), sumatriptan, or tryptophan because the actions and side effects of Meridia may be increased, including increased risk of restlessness, fever, excessive sweating, twitching, and seizures that can, rarely, be life-threatening
• Cyclosporine because the actions and side effects may be increased by Meridia

This may not be a complete list of all interactions that may occur. Ask your health care provider if Meridia may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Meridia :

Use Meridia as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Meridia may be taken with or without food.
• Unless otherwise directed by your doctor, Meridia should be taken in the morning to avoid sleeping problems.
• If you miss a dose of Meridia , skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Meridia .

Important safety information:

• Meridia may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Meridia . Using Meridia alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Meridia . Meridia will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• Changes in dietary habits and increased exercise are important parts of a successful weight loss program. To maintain your ideal weight, these changes should be continued for life. Follow the guidelines given to you by your doctor or diet counselor.
• LAB TESTS, such as blood pressure, pulse monitoring, and weight monitoring, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Use an effective method of birth control while you are taking Meridia .
• Meridia is not recommended for use in CHILDREN and ADOLESCENTS. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Meridia during pregnancy. It is unknown if Meridia is excreted in breast milk. Do not breast-feed while taking Meridia .

When used for long periods of time or at high doses, some people develop a need to continue taking Meridia . This is known as DEPENDENCE or addiction.

Possible side effects of Meridia :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; constipation; dizziness; dry mouth; flu-like symptoms; headache; increased cough; increased or decreased appetite; indigestion; joint pain; migraine; nasal inflammation; nausea; nervousness; painful menstruation; sinus inflammation; sleeplessness; sore throat; upset stomach; weakness.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; anxiety; change in amount of urine; chest pain; clumsiness; confusion; depression; difficulty breathing; disorientation; excitement; eye pain; fainting; fast or irregular heartbeat; high fever; increased sweating; large, unchanging pupils; loss of consciousness; one-sided weakness; restlessness; seizures; shivering; shortness of breath; stomach pain; swelling of the feet, ankles, or legs; tremors; unusual bruising or bleeding; vision problems; vomiting; weakness.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Store Meridia at room temperature, at 77 degrees F (25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Meridia out of the reach of children and away from pets.

General information:

• If you have any questions about Meridia , please talk with your doctor, pharmacist, or other health care provider.
• Meridia is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Meridia . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.